Viral Infection of Human Lung Macrophages Increases PDL1 Expression via IFNβ
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منابع مشابه
Viral Infection of Human Lung Macrophages Increases PDL1 Expression via IFNβ
Lung macrophages are an important defence against respiratory viral infection and recent work has demonstrated that influenza-induced macrophage PDL1 expression in the murine lung leads to rapid modulation of CD8+ T cell responses via the PD1 receptor. This PD1/PDL1 pathway may downregulate acute inflammatory responses to prevent tissue damage. The aim of this study was to investigate the mecha...
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Kohut, M. L., J. M. Davis, D. A. Jackson, P. Jani, A. Ghaffar, E. P. Mayer, and D. A. Essig. Exercise effects on IFN-b expression and viral replication in lung macrophages after HSV-1 infection. Am. J. Physiol. 275 (Lung Cell. Mol. Physiol. 19): L1089–L1094, 1998.—Mice exercised to fatigue and exposed to herpes simplex virus type 1 (HSV-1) exhibit greater mortality than control mice. In this st...
متن کاملExercise effects on IFN-β expression and viral replication in lung macrophages after HSV-1 infection.
Mice exercised to fatigue and exposed to herpes simplex virus type 1 (HSV-1) exhibit greater mortality than control mice. In this study, we examined lung macrophage resistance to HSV-1 after exercise in terms of both viral replication and interferon (IFN)-β production. We utilized the reverse transcriptase-rapid polymerase chain reaction to measure the IFN-β mRNA content in alveolar macrophages...
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Macrophages are essential to maintaining lung homoeostasis and recent work has demonstrated that influenza-infected lung macrophages downregulate their expression of the scavenger receptor CD36. This receptor has also been shown to be involved in phagocytosis of Streptococcus pneumoniae, a primary agent associated with pneumonia secondary to viral infection. The aim of this study was to investi...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0121527